A Gene Involved in the Development of the Posterior Body Region of C. Elegans

Cell. 1986 Aug 1;46(3):477-87. doi: 10.1016/0092-8674(86)90668-9.

Abstract

Many regional differences in Caenorhabditis elegans body pattern are generated after hatching. Here I describe a gene, mab-5, that is required for the postembryonic development of nearly all ectodermal and mesodermal features that normally characterize a posterior body region. In addition, this gene is necessary for most cell migrations toward the posterior, but not for cell migrations toward the anterior. mab-5+ activity is cell-autonomous. In animals carrying a mutation in the gene lin-22, increases or decreases in mab-5+ gene dosage produce corresponding increases or decreases in the size of the region in which cells adopt posterior-specific fates. The model that best explains the data is that during postembryonic development, posterior-specific patterns of cell differentiation and cell migration are initiated by graded positional information, and that a common step in the different cellular responses to this information is mediated by mab-5 activity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Caenorhabditis / genetics*
  • Caenorhabditis / growth & development
  • Cell Differentiation
  • Cell Fusion
  • Cell Movement
  • Cell Survival
  • Female
  • Genes*
  • Male
  • Morphogenesis
  • Mosaicism
  • Phenotype
  • Sex Differentiation