Quantification of Multi-Parametric Magnetic Resonance Imaging Based on Radiomics Analysis for Differentiation of Benign and Malignant Lesions of Prostate

Soheila Koopaei; Anahita Fathi Kazerooni; Mahyar Ghafoori; Mohamadreza Alviri; Fakhereh Pashaei; Hamidreza Saligheh Rad

doi:10.31661/jbpe.v0i0.2008-1158

Quantification of Multi-Parametric Magnetic Resonance Imaging Based on Radiomics Analysis for Differentiation of Benign and Malignant Lesions of Prostate

J Biomed Phys Eng. 2023 Jun 1;13(3):251-260. doi: 10.31661/jbpe.v0i0.2008-1158. eCollection 2023 Jun.

Authors

Soheila Koopaei^{1

2}, Anahita Fathi Kazerooni², Mahyar Ghafoori³, Mohamadreza Alviri², Fakhereh Pashaei^{1

4}, Hamidreza Saligheh Rad^{1

2}

Affiliations

¹ Quantitative MR Imaging and Spectroscopy Group, Research Center for Molecular and Cellular Imaging, Institute for Advanced Medical Technologies, Imam Hospital, Tehran, Iran.
² Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Science Tehran, Iran.
³ Department of Radiology, Hazrat Rasoul Akram University Hospital, Tehran, Iran.
⁴ Radiation Sciences Research Center (RSRC), Aja University of Medical Sciences, Tehran, Iran.

Abstract

Background: The most common cancer (non-cutaneous) malignancy among men is prostate cancer. Management of prostate cancer, including staging and treatment, playing an important role in decreasing mortality rates. Among all current diagnostic tools, multiparametric MRI (mp-MRI) has shown high potential in localizing and staging prostate cancer. Quantification of mp-MRI helps to decrease the dependency of diagnosis on readers' opinions.

Objective: The aim of this research is to set a method based on quantification of mp-MRI images for discrimination between benign and malignant prostatic lesions with fusion-guided MR imaging/transrectal ultrasonography biopsy as a pathology validation reference.

Material and methods: It is an analytical research that 27 patients underwent the mp-MRI examination, including T1- and T2- weighted and diffusion weighted imaging (DWI). Quantification was done by calculating radiomic features from mp-MRI images. Receiver-operating-characteristic curve was done for each feature to evaluate the discriminatory capacity and linear discriminant analysis (LDA) and leave-one-out cross-validation for feature filtering to estimate the sensitivity, specificity and accuracy of the benign and malignant lesion differentiation process is used.

Results: An accuracy, sensitivity and specificity of 92.6%, 95.2% and 83.3%, respectively, were achieved from a subset of radiomics features obtained from T2-weighted images and apparent diffusion coefficient (ADC) maps for distinguishing benign and malignant prostate lesions.

Conclusion: Quantification of mp-MRI (T2-weighted images and ADC-maps) based on radiomics feature has potential to distinguish benign with appropriate accuracy from malignant prostate lesions. This technique is helpful in preventing needless biopsies in patients and provides an assisted diagnosis for classifications of prostate lesions.

Keywords: Multiparametric Magnetic Resonance Imaging; Prostatic Neoplasms; Quantification Analysis; Radiomics Fatures.