Effects of Erythromycin, Josamycin and Spiramycin on Rat Polymorphonuclear Leukocyte Chemotaxis

Chemotherapy. 1986;32(4):379-82. doi: 10.1159/000238438.


The effects of three macrolide antibiotics were studied on rat polymorphonuclear leukocyte chemotaxis. Rats were given 25 mg/kg twice a day of either erythromycin, josamycin or spiramycin by gastric intubation for 5 days. In all cases, chemotaxis was found to be impaired by 10-20% only. As macrolides are known to reach high intracellular concentrations within polymorphonuclear leukocytes, our results suggest that these antibiotics are unlikely to exert a deleterious influence on the chemotactic response of treated patients.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Chemotaxis, Leukocyte / drug effects*
  • Erythromycin / pharmacology*
  • Female
  • Leucomycins / pharmacology*
  • Neutrophils / drug effects*
  • Rats
  • Rats, Inbred Strains


  • Leucomycins
  • Erythromycin