Cellular Membrane Components-Mediated Cancer Immunotherapeutic Platforms

Macromol Biosci. 2023 Nov;23(11):e2300159. doi: 10.1002/mabi.202300159. Epub 2023 Jun 25.


Immune cell engineering is an active field of ongoing research that can be easily applied to nanoscale biomedicine as an alternative to overcoming limitations of nanoparticles. Cell membrane coating and artificial nanovesicle technology have been reported as representative methods with an advantage of good biocompatibility for biomimetic replication of cell membrane characteristics. Cell membrane-mediated biomimetic technique provides properties of natural cell membrane and enables membrane-associated cellular/molecular signaling. Thus, coated nanoparitlces (NPs) and artificial nanovesicles can achieve effective and extended in vivo circulation, enabling execution of target functions. While coated NPs and artificial nanovesicles provide clear advantages, much work remains before clinical application. In this review, first a comprehensive overview of cell membrane coating techniques and artificial nanovesicles is provided. Next, the function and application of various immune cell membrane types are summarized.

Keywords: artificial nanovesicles; cancer immunotherapy; cell membrane; cell membrane-coated nanoparticles; immune cells; receptor/ligand interactions.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomimetic Materials*
  • Cell Membrane
  • Humans
  • Immunotherapy
  • Nanoparticles*
  • Neoplasms* / therapy