Cerebrospinal fluid soluble CD27 is associated with CD8+ T cells, B cells and biomarkers of B cell activity in relapsing-remitting multiple sclerosis

J Neuroimmunol. 2023 Aug 15:381:578128. doi: 10.1016/j.jneuroim.2023.578128. Epub 2023 Jun 9.

Abstract

Cerebrospinal fluid (CSF) soluble CD27 (sCD27) is a sensitive biomarker of intrathecal inflammation. Although generally considered a biomarker of T cell activation, CSF sCD27 has been shown to correlate with biomarkers of B cell activity in multiple sclerosis. We analyzed CSF from 40 patients with relapsing-remitting multiple sclerosis (RRMS) and nine symptomatic controls using flow cytometry and multiplex electrochemiluminescence immunoassays. CSF sCD27 levels were increased in RRMS and correlated with IgG index, soluble B cell maturation antigen, cell count, B cell frequency and CD8+ T cell frequency. We provide new data indicating that CSF sCD27 is associated with CD8+ T cells and B cells in RRMS.

Keywords: CSF; Intrathecal inflammation; Lymphocytes; RRMS; sBCMA; sCD27.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • B-Lymphocytes
  • Biomarkers / cerebrospinal fluid
  • CD8-Positive T-Lymphocytes
  • Humans
  • Multiple Sclerosis*
  • Multiple Sclerosis, Relapsing-Remitting* / cerebrospinal fluid
  • Multiple Sclerosis, Relapsing-Remitting* / diagnosis
  • Tumor Necrosis Factor Receptor Superfamily, Member 7* / chemistry
  • Tumor Necrosis Factor Receptor Superfamily, Member 7* / metabolism

Substances

  • Biomarkers
  • Tumor Necrosis Factor Receptor Superfamily, Member 7