Clinical features and therapeutic management of choroidal osteoma: A systematic review

Surv Ophthalmol. 2023 Nov-Dec;68(6):1084-1092. doi: 10.1016/j.survophthal.2023.06.002. Epub 2023 Jun 14.


Choroidal osteoma is a benign ossifying tumor within the choroid. Complications associated with choroidal osteoma, including disruption of retinal pigment epithelium, atrophy of photoreceptors, subretinal fluid, and choroidal neovascularization, present challenges for clinicians, and management remain controversial. We performed a comprehensive search in the PubMed, EMBASE, and Ovid databases for published studies and case reports relating to the management of choroidal osteoma. Since it was first described in 1978, various case reports of ocular complications associated with choroidal osteoma have been documented, and various therapies have yielded different outcomes. We systematically evaluate the literature published on this rare entity.

Keywords: Anti-VEGF agents; Choroidal neovascularization; Choroidal osteoma; Subretinal fluid; Systematic review.

Publication types

  • Systematic Review
  • Review

MeSH terms

  • Choroid / pathology
  • Choroid Neoplasms* / complications
  • Choroid Neoplasms* / diagnosis
  • Choroid Neoplasms* / therapy
  • Choroidal Neovascularization* / drug therapy
  • Fluorescein Angiography
  • Humans
  • Osteoma* / complications
  • Osteoma* / diagnosis
  • Osteoma* / therapy
  • Retinal Pigment Epithelium / pathology
  • Tomography, Optical Coherence