Hydrophilic chitosan/graphene oxide composite sponge for rapid hemostasis and non-rebleeding removal

Abstract

Hydrophilic hemostatic sponge plays an important role in trauma bleeding control because of its robust coagulant functions. However, its strong tissue adhesion can easily result in wound tear and rebleeding during removing the sponge. Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported. For one thing, CSAG exhibits outstanding hemostatic performance, which significantly outperforms two commercial hemostats in two in vivo serious bleeding models. For another, CSAG shows low tissue adhesion; its peeling force is approximately 79.3 % lower than the commercial gauze. Moreover, in the peeling process, CSAG triggers partial detachment of the blood scab, because of the exist of bubbles or cavities at the interface, allowing the CSAG to be easily and safely peeled off from the wound without rebleeding. This study opens new avenues in constructing anti-adhesive trauma hemostatic materials.

Keywords: Ammonium persulfate (PubChem CID: 62648); Anti-adhesion; Chitosan (PubChem CID: 71853); Graphene oxide; Graphite powders (PubChem CID: 5462310); Hydrochloric acid (PubChem CID: 313); Hydrogen peroxide (PubChem CID: 784); Hydrophilic hemostatic sponge; Methacrylic anhydride (PubChem CID: 12974); N,N′-Methylenebisacrylamide (PubChem CID: 8041); Non-rebleeding removal; Potassium permanganate (PubChem CID: 516875); Rapid hemostasis; Sodium nitrate (PubChem CID: 24268); Sulfuric acid (PubChem CID: 1118).