Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior

Fatemeh Sadat Mirfazeli; Fatemeh Mohebi; Amin Jahanbakhshi; Omid Aryani; Mostafa Almasi-Dooghaee

doi:10.32598/bcn.2021.910.3

Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior

Basic Clin Neurosci. 2022 Nov-Dec;13(6):893-900. doi: 10.32598/bcn.2021.910.3. Epub 2022 Nov 1.

Authors

Fatemeh Sadat Mirfazeli¹, Fatemeh Mohebi², Amin Jahanbakhshi³, Omid Aryani^{4

5}, Mostafa Almasi-Dooghaee⁶

Affiliations

¹ Mental Health Research Center, Psychosocial Health Research Institute, Iran University of Medical Sciences, Tehran, Iran.
² Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
³ Skull Base Research Center, Department of Neurosurgery, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
⁴ Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
⁵ Department of Neuroscience, Faculty of New Medical Technologies, Iran University of Medical Sciences, Tehran, Iran.
⁶ Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.

Abstract

Wolfram syndrome (WS) is a rare autosomal recessive neurodegenerative disease with variable symptoms, including neuropsychiatric manifestations. A 26-year-old man was reported with classic symptoms of WS and repetitive psychiatric hospitalizations and at least 16 suicidal attempts. The genetic study demonstrated a novel homozygous stop-codon mutation on the WFS1 gene. This special type of mutation may be related to repetitive suicidal behaviors in this case of WS. Psychological support should be a routine practice in patients with WS.

Keywords: Gene; Mutation; Suicidal behavior; WFS1 gene; Wolfram syndrome.

Publication types

Case Reports