The effect of methylprednisolone on the pulmonary accumulation of transferrin in the adult respiratory distress syndrome

Eur J Respir Dis. 1986 May;68(5):336-41.

Abstract

Plasma protein accumulation (PPA) was monitored in the lungs of patients with the adult respiratory distress syndrome (ARDS). Transferrin radiolabelled in vivo with indium-113m was used as the plasma protein marker. Ten patients with clinically defined ARDS, exhibiting increased PPA indices (greater than 1.0 X 10(-3) min-1), were given intravenous infusion of methylprednisolone (MP; 30 mg kg-1 over 10 min). The four patients in whom the PPA indices were reduced to below 0.5 X 10(-3) min-1 within 1 h of completion of MP infusion all survived. In the remaining six patients PPA indices remained above 0.5 X 10(-3) min-1 and five of them died. The PPA indices prior to administration of MP were not significantly different in the survivors (n = 5) and non-survivors (n = 5); however, after MP they were significantly lower in the survivors compared with the non-survivors (P less than 0.02). Thus the response to an infusion of MP, monitored as PPA, may provide a predictor of survival in ARDS.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Capillary Permeability
  • Female
  • Humans
  • Indium*
  • Lung / diagnostic imaging*
  • Lung / metabolism
  • Male
  • Methylprednisolone / therapeutic use*
  • Middle Aged
  • Radioisotopes*
  • Radionuclide Imaging
  • Respiratory Distress Syndrome / diagnostic imaging
  • Respiratory Distress Syndrome / drug therapy*
  • Respiratory Distress Syndrome / metabolism
  • Time Factors
  • Transferrin*

Substances

  • Radioisotopes
  • Transferrin
  • Indium
  • Methylprednisolone