Senescent Macrophages Promote KRAS-Driven Lung Tumorigenesis

Cancer Discov. 2023 Aug 4;13(8):1758. doi: 10.1158/2159-8290.CD-RW2023-092.

Abstract

Senescent macrophages in the tumor microenvironment support lung tumor initiation and immunosuppression.

Publication types

  • Comment

MeSH terms

  • Carcinogenesis / genetics
  • Carcinogenesis / pathology
  • Cell Transformation, Neoplastic
  • Humans
  • Lung / pathology
  • Lung Neoplasms* / genetics
  • Lung Neoplasms* / pathology
  • Macrophages / pathology
  • Proto-Oncogene Proteins p21(ras) / genetics
  • Tumor Microenvironment / genetics

Substances

  • Proto-Oncogene Proteins p21(ras)
  • KRAS protein, human