Reversing the mitochondrial hex that bewitches NLRP3

Manasa Mellacheruvu; Grace M E P Lawrence; Stefan Emming; Kate Schroder

doi:10.1126/sciimmunol.adh2967

Reversing the mitochondrial hex that bewitches NLRP3

Sci Immunol. 2023 Jun 23;8(84):eadh2967. doi: 10.1126/sciimmunol.adh2967. Epub 2023 Jun 16.

Authors

Manasa Mellacheruvu¹, Grace M E P Lawrence¹, Stefan Emming¹, Kate Schroder¹

Affiliation

¹ Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD, Australia.

PMID: 37327323
DOI: 10.1126/sciimmunol.adh2967

Abstract

Hexokinase dissociation from mitochondria triggers calcium-induced oligomerization of VDAC within the outer mitochondrial membrane, leading to NLRP3 recruitment and inflammasome signaling (see related Research Article by Baik et al.).

Publication types

Review

MeSH terms

Inflammasomes / metabolism
Mitochondria*
Mitochondrial Membranes / metabolism
NLR Family, Pyrin Domain-Containing 3 Protein* / metabolism
Signal Transduction

Substances

NLR Family, Pyrin Domain-Containing 3 Protein
Inflammasomes