Prognostic significance of growth characteristics of xenotransplanted ovarian carcinomas into nude mice

Gynecol Oncol. 1986 Sep;25(1):65-72. doi: 10.1016/0090-8258(86)90066-1.

Abstract

Human ovarian carcinomas (n = 215) were xenotransplanted into thymus-aplastic female nu/nu mice (NMRI). Growth of transplants was defined as take-off rate, growth rapidity, and feasibility of passages. In 204 cases these growth characteristics could be correlated with survival time of the individual tumor-donor patients. It could be shown that median survival time of patients without take-off was longer than with take-off. In the same way there was a significant difference between slow- and fast-growing transplants as well as in tumors with only one animal passage and with more than three passages. A life table analysis similarly shows that a good growth of a xenotransplanted human ovarian carcinoma into nude mice is correlated with a poor prognosis of individual patients. It could be demonstrated that at least in ovarian cancer growth of xenotransplants in nude mice indicates a prognostic significance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Female
  • Humans
  • Mice
  • Mice, Nude
  • Neoplasm Transplantation
  • Ovarian Neoplasms / pathology*
  • Prognosis
  • Transplantation, Heterologous