Multivariate analysis of prognostic factors in fulminant hepatitis B

Hepatology. Jul-Aug 1986;6(4):648-51. doi: 10.1002/hep.1840060417.

Abstract

We assessed prognostic factors in 115 patients with serologically defined fulminant hepatitis B. The diagnosis in each case was based on the finding of IgM antibody to the hepatitis B core antigen in serum. Multivariate analysis showed that factor V level (p less than 0.001), patient's age (p = 0.001), absence of detectable HBsAg by radioimmunoassay (p = 0.06) and serum alpha-fetoprotein concentration (p = 0.07) were independent predictors of survival. The survival rate in the 21 patients in whom HBsAg was not detected was 47%, which was significantly higher than the survival rate of 17% observed in the 94 HBsAg-positive patients (p = 0.006). In patients with fulminant hepatitis B, the absence of HBsAg in serum as detected by radioimmunoassay has an independent, favorable prognostic value.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Antibodies, Viral / analysis
  • Factor V / analysis
  • Female
  • Hepatitis B / immunology*
  • Hepatitis B / mortality
  • Hepatitis B Core Antigens / immunology
  • Hepatitis B Surface Antigens / analysis
  • Homosexuality
  • Humans
  • Immunoglobulin M / analysis
  • Male
  • Middle Aged
  • Pregnancy
  • Prognosis
  • Sex Factors
  • Statistics as Topic
  • Time Factors

Substances

  • Antibodies, Viral
  • Hepatitis B Core Antigens
  • Hepatitis B Surface Antigens
  • Immunoglobulin M
  • Factor V