Marginal metallophilic cells of the mouse spleen identified by a monoclonal antibody

Immunology. 1986 Aug;58(4):665-9.


A monoclonal antibody, MOMA-1, is described that recognizes the marginal metallophilic macrophages in the mouse spleen. The cells are localized at the marginal sinus forming a ring around the periarteriolar lymphocyte sheath and follicular areas at the inner side of the marginal zone. They show high non-specific esterase activity and can be distinguished from the marginal zone macrophages by antibody staining and the lack of FITC-Ficoll uptake. The relationship of MOMA-1-positive cells with other macrophage populations is discussed.

MeSH terms

  • Acid Phosphatase / metabolism
  • Animals
  • Antibodies, Monoclonal / immunology*
  • Carboxylic Ester Hydrolases / metabolism
  • Intestine, Small / cytology
  • Lymph Nodes / cytology
  • Macrophages / enzymology
  • Macrophages / immunology*
  • Mice
  • Mice, Inbred Strains
  • Rats
  • Rats, Inbred Strains
  • Spleen / cytology*
  • Spleen / enzymology


  • Antibodies, Monoclonal
  • Carboxylic Ester Hydrolases
  • Acid Phosphatase