Otorrhea bacterial profile, epidemiology before widespread use of the third-generation pneumococcal conjugate vaccine in French children, a prospective study from 2015 to 2023

Corinne Levy; Emmanuelle Varon; Philippe Bidet; Stéphane Béchet; Christophe Batard; Alain Wollner; Franck Thollot; Stéphane Bonacorsi; Robert Cohen

doi:10.1016/j.idnow.2023.104738

Otorrhea bacterial profile, epidemiology before widespread use of the third-generation pneumococcal conjugate vaccine in French children, a prospective study from 2015 to 2023

Infect Dis Now. 2023 Sep;53(6):104738. doi: 10.1016/j.idnow.2023.104738. Epub 2023 Jun 17.

Authors

Corinne Levy¹, Emmanuelle Varon², Philippe Bidet³, Stéphane Béchet⁴, Christophe Batard⁴, Alain Wollner⁴, Franck Thollot⁴, Stéphane Bonacorsi³, Robert Cohen⁵

Affiliations

¹ ACTIV, Association Clinique et Thérapeutique Infantile du Val-de-Marne, Créteil, France; Clinical Research Center (CRC), Centre Hospitalier Intercommunal de Créteil, Créteil, France; Université Paris Est, IMRB-GRC GEMINI, Créteil, France; AFPA, Association Française de Pédiatrie Ambulatoire, Orléans, France. Electronic address: corinne.levy@activ-france.fr.
² Service de microbiologie, Hôpital Intercommunal de Créteil, Créteil, France.
³ Université Paris Cité, IAME, INSERM, F-75018 Paris, France; Service de microbiologie, Hôpital Robert-Debré, AP-HP, Paris, France.
⁴ ACTIV, Association Clinique et Thérapeutique Infantile du Val-de-Marne, Créteil, France; AFPA, Association Française de Pédiatrie Ambulatoire, Orléans, France.
⁵ ACTIV, Association Clinique et Thérapeutique Infantile du Val-de-Marne, Créteil, France; Clinical Research Center (CRC), Centre Hospitalier Intercommunal de Créteil, Créteil, France; Université Paris Est, IMRB-GRC GEMINI, Créteil, France; AFPA, Association Française de Pédiatrie Ambulatoire, Orléans, France.

PMID: 37331698
DOI: 10.1016/j.idnow.2023.104738

Abstract

Objectives: The aim of this study was to describe the bacterial profile of middle ear fluid from spontaneous perforation of the tympanic membrane (SPTM) prior to widespread utilization of third- generation pneumococcal conjugate vaccines (PCVs).

Patients and methods: From October 2015 to January 2023, children with SPTM were prospectively enrolled by pediatricians.

Results: Among the 852 children with SPTM, 73.2% were less than 3 years old; more frequently than older children, they were and suffering from complex acute otitis media (AOM) (27.9%) and conjunctivitis (13.1%). In children under 3 years of age, NT Haemophilus influenzae (49.7%) was the main otopathogen isolated, particularly in those with complex AOM (57.1%). In children over 3 years of age, Group A Streptococcus accounted for 57%. In pneumococcal cases (25.1%), serotype 3 was the main serotype isolated (16.2%), followed by 23B (15.2%).

Conclusion: Our data from 2015 to 2023 represent a robust baseline preceding the widespread utilization of next-generation PCVs.

Keywords: Group A Streptococcus; Heamophilus influenzae; Otorrhea; Pneumococcal conjugate vaccines; Streptococcus pneumoniae.

MeSH terms

Adolescent
Bacteria
Child
Child, Preschool
Humans
Otitis Media* / epidemiology
Otitis Media* / microbiology
Otitis Media* / prevention & control
Prospective Studies
Streptococcus pneumoniae
Vaccines, Conjugate

Substances

Vaccines, Conjugate