[Research progress of optic atrophy 1-mediated mitochondrial dynamics in skeletal system diseases]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2023 Jun 15;37(6):758-763. doi: 10.7507/1002-1892.202302056.
[Article in Chinese]

Abstract

Objective: To review the research progress of mitochondrial dynamics mediated by optic atrophy 1 (OPA1) in skeletal system diseases.

Methods: The literatures about OPA1-mediated mitochondrial dynamics in recent years were reviewed, and the bioactive ingredients and drugs for the treatment of skeletal system diseases were summarized, which provided a new idea for the treatment of osteoarthritis.

Results: OPA1 is a key factor involved in mitochondrial dynamics and energetics and in maintaining the stability of the mitochondrial genome. Accumulating evidence indicates that OPA1-mediated mitochondrial dynamics plays an important role in the regulation of skeletal system diseases such as osteoarthritis, osteoporosis, and osteosarcoma.

Conclusion: OPA1-mediated mitochondrial dynamics provides an important theoretical basis for the prevention and treatment of skeletal system diseases.

目的: 对视神经萎缩因子1(optic atrophy 1,OPA1)介导的线粒体动力学在骨骼系统疾病中的研究进展进行综述。.

方法: 查阅近年关于OPA1介导的线粒体动力学相关文献,总结治疗骨骼系统疾病的生物活性成分及药物,为治疗骨关节炎提供新的思路。.

结果: OPA1是参与线粒体动力学和能量学及维持线粒体基因组稳定的关键因子,越来越多证据表明OPA1介导的线粒体动力学在调控骨关节炎、骨质疏松、骨肉瘤等骨骼系统疾病方面有重要意义。.

结论: OPA1介导的线粒体动力学在防治骨骼系统疾病方面提供了重要的理论依据。.

Keywords: Mitochondrial quality control; disorder of skeletal system; mitochondrial dynamics; optic atrophy 1.

Publication types

  • Review
  • English Abstract

MeSH terms

  • GTP Phosphohydrolases* / genetics
  • Humans
  • Mitochondrial Dynamics
  • Osteoarthritis*
  • Osteoporosis*

Substances

  • GTP Phosphohydrolases
  • OPA1 protein, human

Grants and funding

国家自然科学基金资助项目(81974347、82272561);四川省科技厅重点研发项目(2022YFS0050、2023YFS0096);中国博士后基金资助项目(2021M702351);四川省卫生健康委员会医学科技项目(21PJ040)