Coronary microvascular dysfunction in heart failure patients

Front Cardiovasc Med. 2023 Jun 2:10:1153994. doi: 10.3389/fcvm.2023.1153994. eCollection 2023.


Coronary microcirculation has multiple layers of autoregulatory function to maintain resting flow and augment hyperemic flow in response to myocardial demands. Functional or structural alterations in the coronary microvascular function are frequently observed in patients with heart failure with preserved or reduced ejection fraction, which may lead to myocardial ischemic injury and resultant worsening of clinical outcomes. In this review, we describe our current understanding of coronary microvascular dysfunction in the pathogenesis of heart failure with preserved and reduced ejection fraction.

Keywords: coronary flow reserve; coronary microvascular dysfunction; coronary physiology; heart failure with preserved ejection fraction; heart failure with reduced ejection fraction.

Publication types

  • Review