Clinical Implications of Dystonia as a Neural Network Disorder

Giovanni Battistella; Kristina Simonyan

doi:10.1007/978-3-031-26220-3_13

Clinical Implications of Dystonia as a Neural Network Disorder

Adv Neurobiol. 2023:31:223-240. doi: 10.1007/978-3-031-26220-3_13. Epub 2023 Jun 21.

Authors

Giovanni Battistella¹, Kristina Simonyan^{2

3}

Affiliations

¹ Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA.
² Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA. kristina_simonyan@meei.harvard.edu.
³ Department of Neurology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA. kristina_simonyan@meei.harvard.edu.

Abstract

Isolated dystonia is a neurological disorder of diverse etiology, multifactorial pathophysiology, and wide spectrum of clinical presentations. We review the recent neuroimaging advances that led to the conceptualization of dystonia as a neural network disorder and discuss how current knowledge is shaping the identification of biomarkers of dystonia and the development of novel pharmacological therapies.

Keywords: Connectome; Functional connectivity; Network disorder; Neurotransmission; Structural networks.

Publication types

Review

MeSH terms

Brain
Connectome* / methods
Dystonia* / diagnostic imaging
Dystonic Disorders* / diagnostic imaging
Humans
Magnetic Resonance Imaging

Abstract

Publication types

MeSH terms

Grants and funding