Clinical Implications of Dystonia as a Neural Network Disorder

Adv Neurobiol. 2023:31:223-240. doi: 10.1007/978-3-031-26220-3_13. Epub 2023 Jun 21.


Isolated dystonia is a neurological disorder of diverse etiology, multifactorial pathophysiology, and wide spectrum of clinical presentations. We review the recent neuroimaging advances that led to the conceptualization of dystonia as a neural network disorder and discuss how current knowledge is shaping the identification of biomarkers of dystonia and the development of novel pharmacological therapies.

Keywords: Connectome; Functional connectivity; Network disorder; Neurotransmission; Structural networks.

Publication types

  • Review

MeSH terms

  • Brain
  • Connectome* / methods
  • Dystonia* / diagnostic imaging
  • Dystonic Disorders* / diagnostic imaging
  • Humans
  • Magnetic Resonance Imaging