Omentin-1 drives cardiomyocyte cell cycle arrest and metabolic maturation by interacting with BMP7

Cell Mol Life Sci. 2023 Jun 21;80(7):186. doi: 10.1007/s00018-023-04829-1.


Mammalian cardiomyocytes (CMs) undergo maturation during postnatal heart development to meet the increased demands of growth. Here, we found that omentin-1, an adipokine, facilitates CM cell cycle arrest and metabolic maturation. Deletion of omentin-1 causes mouse heart enlargement and dysfunction in adulthood and CM maturation retardation in juveniles, including delayed cell cycle arrest and reduced fatty acid oxidation. Through RNA sequencing, molecular docking analysis, and proximity ligation assays, we found that omentin-1 regulates CM maturation by interacting directly with bone morphogenetic protein 7 (BMP7). Omentin-1 prevents BMP7 from binding to activin type II receptor B (ActRIIB), subsequently decreasing the downstream pathways mothers against DPP homolog 1 (SMAD1)/Yes-associated protein (YAP) and p38 mitogen-activated protein kinase (p38 MAPK). In addition, omentin-1 is required and sufficient for the maturation of human embryonic stem cell-derived CMs. Together, our findings reveal that omentin-1 is a pro-maturation factor for CMs that is essential for postnatal heart development and cardiac function maintenance.

Keywords: BMP7; Cardiomyocyte; Cell cycle arrest; Cell metabolism; Omentin-1; Postnatal heart development; hES-CMs.

MeSH terms

  • Animals
  • Bone Morphogenetic Protein 7* / metabolism
  • Cell Cycle Checkpoints
  • Cell Differentiation
  • Humans
  • Mice
  • Molecular Docking Simulation
  • Myocytes, Cardiac* / metabolism
  • p38 Mitogen-Activated Protein Kinases / metabolism


  • BMP7 protein, human
  • Bone Morphogenetic Protein 7
  • p38 Mitogen-Activated Protein Kinases
  • Itln1 protein, mouse