Müller Glia to Müller Glia Extracellular Vesicle-Dependent Signaling Induces Multipotency Genes Nestin and l in28 Expression in Response to N-methyl-D-aspartate (NMDA) Exposure

Ana Karen Carapia; Erick J Martinez-Colin; Deisy Segura-Villalobos; Rebeca Yael Victoria-Chavez; Ivonne Lezama; Eduardo Martinez-Martinez; Monica Lamas

doi:10.1177/17590914231183272

Müller Glia to Müller Glia Extracellular Vesicle-Dependent Signaling Induces Multipotency Genes Nestin and l in28 Expression in Response to N-methyl-D-aspartate (NMDA) Exposure

ASN Neuro. 2023 Jan-Dec:15:17590914231183272. doi: 10.1177/17590914231183272.

Authors

Ana Karen Carapia^{1

2}, Erick J Martinez-Colin^{1

2}, Deisy Segura-Villalobos^{1

2}, Rebeca Yael Victoria-Chavez^{1

2}, Ivonne Lezama^{1

2}, Eduardo Martinez-Martinez³, Monica Lamas^{1

2}

Affiliations

¹ Departamento de Farmacobiología, CINVESTAV, Ciudad de Mexico, México.
² Centro de Investigacion sobre el envejecimiento, CINVESTAV, Ciudad de Mexico, México.
³ Laboratorio de Comunicación Celular y Vesículas Extracelulares, Instituto Nacional de Medicina Genómica, Ciudad de Mexico, México.

Abstract

Retinal Müller cells secrete extracellular vesicles that can be captured by other Müller cells. In response to a signal that may be deleterious for the retina, Müller glia-derived extracellular vesicles spread instructions to induce gene expression changes in other cells.

Keywords: Müller glia; dedifferentiation; extracellular vesicles; retina; stem cell.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Proliferation / physiology
Ependymoglial Cells / metabolism
Extracellular Vesicles*
N-Methylaspartate*
Nestin / metabolism
Neuroglia
Retina / metabolism

Substances

N-Methylaspartate
Nestin