ACMG SF v3.2 list for reporting of secondary findings in clinical exome and genome sequencing: A policy statement of the American College of Medical Genetics and Genomics (ACMG)

Genet Med. 2023 Aug;25(8):100866. doi: 10.1016/j.gim.2023.100866. Epub 2023 Jun 22.


Clinicians are encouraged to document the reasons for the use of a particular procedure or test, whether or not it is in conformance with this statement. Clinicians also are advised to take notice of the date this statement was adopted, and to consider other medical and scientific information that becomes available after that date. It also would be prudent to consider whether intellectual property interests may restrict the performance of certain tests and other procedures. Where individual authors are listed, the views expressed may not reflect those of authors’ employers or affiliated institutions.

Keywords: Exome sequencing; Genome sequencing; Incidental findings; Secondary findings.

Publication types

  • Practice Guideline

MeSH terms

  • Base Sequence
  • Exome* / genetics
  • Genetic Testing
  • Genetics, Medical*
  • Genome, Human / genetics
  • Genomics
  • Humans
  • Incidental Findings
  • Policy
  • United States