Evaluation of the efficacy of an antioxidant combination for the modulation of metabolic, endocrine, and clinical parameters in patients with polycystic ovary syndrome

Gynecol Endocrinol. 2023 Jun 19;39(1):2227277. doi: 10.1080/09513590.2023.2227277.


Objective: To evaluate the efficacy of dietary supplementation with a combination of antioxidants (lipoic acid, N-acetylcysteine, vitamin B6, and S-adenosyl-L-methionine) for the modulation of metabolic, endocrine, and clinical parameters in comparison with oral contraception in non-diabetic women newly diagnosed with polycystic ovary syndrome (PCOS).

Methods: This was a prospective, partially randomized, multicenter study in which non-diabetic women with PCOS were recruited under routine clinical practice conditions and distributed in three groups to receive the following regimen for 6 months: 1) antioxidant combination (MN group); 2) oral contraception (OC group); or 3) oral contraception and the antioxidant combination (MN + OC group). General recommendation of healthy diet and regular exercise was given to all patients. Metabolic, endocrine, clinical, and quality of life parameters were recorded at baseline and after 6 months of therapy.

Results: A total of 96 women with PCOS were included in the study. After 6 months of treatment, the homeostasis model assessment-estimated insulin resistance (HOMA-IR) level was reduced only in the MN group, with a significant mean reduction of -0.92 points. Androstenedione was significantly reduced in all groups. Clinical parameters that significantly improved in all groups were hirsutism, acne, irregular menstruation, and quality of life, with no statistical differences between the groups.

Conclusions: This study showed that the antioxidant combination might be a suitable therapy for patients with PCOS when oral contraceptive is not indicated, because in all groups clinical parameters, irregular menstruation as well as androstenedione and quality of life were significantly improved with no statistical difference between groups.

Keywords: S-adenosyl-L-methionine; antioxidant; clinical practice; metabolic parameters; supplementation.

Publication types

  • Randomized Controlled Trial
  • Multicenter Study

MeSH terms

  • Androstenedione
  • Antioxidants* / therapeutic use
  • Contraceptives, Oral* / therapeutic use
  • Dietary Supplements
  • Female
  • Humans
  • Insulin Resistance*
  • Menstruation Disturbances*
  • Polycystic Ovary Syndrome* / diagnosis
  • Prospective Studies
  • Quality of Life


  • Androstenedione
  • Antioxidants
  • Contraceptives, Oral