Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats

Jiaxin Liu; Chuanshang Cao; Yiran Jin; Yan Wang; Xiaona Ma; Jiahui Li; Songlin Guo; Jiancheng Yang; Jianguo Niu; Xueyun Liang

doi:10.1016/j.isci.2023.107022

Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats

iScience. 2023 Jun 7;26(7):107022. doi: 10.1016/j.isci.2023.107022. eCollection 2023 Jul 21.

Authors

Affiliations

¹ Key Laboratory of Ningxia Stem Cell and Regenerative Medicine, Institute of Medical Sciences, General Hospital of Ningxia Medical University, 750001 Yinchuan, China.
² Ningxia Key Laboratory of Cerebrocranial Diseases, Ningxia Medical University, 750004 Yinchuan, China.

Abstract

Intracerebral hemorrhage usually manifests as strong neuroinflammation and neurological deficits. There is an urgent need to explore effective methods for the treatment of intracerebral hemorrhage. The therapeutic effect and the possible mechanism of induced neural stem cell transplantation in an intracerebral hemorrhage rat model are still unclear. Our results showed that transplantation of induced neural stem cells could improve neurological deficits by inhibiting inflammation in an intracerebral hemorrhage rat model. Additionally, induced neural stem cell treatment could effectively suppress microglial pyroptosis, which might occur through inhibiting the NF-κB signaling pathway. Induced neural stem cells could also regulate the polarization of microglia and promote the transition of microglia from pro-inflammatory phenotypes to anti-inflammatory phenotypes to exert their anti-inflammatory effects. Overall, induced neural stem cells may be a promising tool for the treatment of intracerebral hemorrhage and other neuroinflammatory diseases.

Keywords: Cellular neuroscience; Pathophysiology; Stem cells research.