cCMP and cUMP phosphodiesterases in viral infections

Roland Seifert; Joachim J Bugert

doi:10.1016/j.tibs.2023.05.013

cCMP and cUMP phosphodiesterases in viral infections

Trends Biochem Sci. 2023 Oct;48(10):835-838. doi: 10.1016/j.tibs.2023.05.013. Epub 2023 Jun 24.

Authors

Roland Seifert¹, Joachim J Bugert²

Affiliations

¹ Institute of Pharmacology, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany. Electronic address: seifert.roland@mh-hannover.de.
² Institute of Microbiology of the Bundeswehr, Neuherbergstrasse 11, D-80937 Munich, Germany.

PMID: 37365086
DOI: 10.1016/j.tibs.2023.05.013

Abstract

In bacteria, cCMP and cUMP have a key role in defense against infection with bacterial viruses. Bacteriophages encode phosphodiesterases (PDEs; 'nucleases'; Apyc1), which cleave cCMP/cUMP, counteracting this defense. We propose that PDEs are of broader biological relevance, including cCMP/cUMP-cleaving PDEs of eukaryotic viruses, which may constitute new drug targets.

Keywords: Pycsar; anti-Pycsar (Apyc); drug targets; phosphodiesterases (PDEs); poxins; virus infections.

MeSH terms

Cyclic CMP
Humans
Nucleotides, Cyclic
Phosphoric Diester Hydrolases*
Virus Diseases*

Substances

cyclic 3',5'-uridine monophosphate
Phosphoric Diester Hydrolases
Cyclic CMP
diethylstilbestrol monophosphate
Nucleotides, Cyclic