Effect of L-dopa on visual evoked potential in patients with Parkinson's disease

Neurology. 1986 Aug;36(8):1119-21. doi: 10.1212/wnl.36.8.1119.

Abstract

In 47 patients with Parkinson's disease, we studied the visual evoked potential (VEP) using the pattern-reversal checkerboard (CBVEP) and the grating (GVEP) stimuli before and after 3 months of L-dopa therapy. The P100 latency in both CBVEP and GVEP was prolonged before L-dopa therapy, usually commensurate with the degree of motor disability. Clinical improvement of the parkinsonian state after L-dopa therapy was associated with shortening of the P100 latency in CBVEP, but not significantly in GVEP.

MeSH terms

  • Aged
  • Evoked Potentials, Visual*
  • Female
  • Humans
  • Levodopa / pharmacology
  • Levodopa / therapeutic use*
  • Male
  • Middle Aged
  • Parkinson Disease / drug therapy*
  • Parkinson Disease / physiopathology
  • Pattern Recognition, Visual

Substances

  • Levodopa