Determination of Vitamin B12 and Folate Compounds in Commercially Available Edible Seaweed Products

Front Biosci (Elite Ed). 2023 May 5;15(2):10. doi: 10.31083/j.fbe1502010.

Abstract

Background: Information on the contents of both vitamin B12 and folate in edible seaweeds is limited, of which deficiencies disrupt methionine biosynthesis to accumulate homocysteine as a risk factor of cardiovascular diseases.

Methods: Both vitamins were determined in commercially available edible seaweed products using high-performance liquid chromatography.

Results: Dried purple laver (Neopyropia yezoensis) products contain higher levels of vitamin B12 (approximately 30-60 μg/100 g dry weight) and folate compounds (approximately 880-1300 μg/100 g dry weight) than other seaweed products, such as kombu (Saccharina japonica), hijiki (Sargassum fusiformis), and wakame (Undaria pinnatifida). 5-methyltetrahydrofolate was the major folate compound in purple laver products. 5-formyltetrahydrofolate was found at a moderate level, whereas tetrahydrofolate, 5,10-metenyltetrahydrofolate, 10-formyltetrahydrofolate, and folic acid were found to be minor folate compounds.

Conclusions: These findings suggest that dried purple laver (nori) products are suitable sources of vitamin B12 and folate compounds for humans, especially vegetarians.

Keywords: edible seaweeds; folates; nutrients; purple laver; vitamin B12.

MeSH terms

  • Chromatography, High Pressure Liquid
  • Folic Acid
  • Humans
  • Seaweed* / chemistry
  • Vitamin B 12* / analysis
  • Vitamin B 12* / chemistry
  • Vitamins / analysis

Substances

  • Vitamin B 12
  • Folic Acid
  • Vitamins