Epstein-Barr viral stromal keratitis

Ophthalmology. 1986 Jun;93(6):746-51. doi: 10.1016/s0161-6420(86)33668-6.


We have identified seven patients with clinical and serological features suggestive of Epstein-Barr viral (EBV) stromal keratitis. Four had discrete, sharply demarcated, multifocal, pleomorphic or ring-shaped granular anterior stromal opacities with normal intervening stroma, seemingly distinct from adenoviral or herpes simplex stromal keratitis. Two had soft, blotchy, pleomorphic, multifocal infiltrates, predominantly involving the peripheral cornea at all depths, and with minimal neovascularization, resembling syphilitic stromal keratitis. One patient had features or both forms of keratitis. OUr experience suggests that EBV may be more commonly associated with stromal keratitis than recognized previously.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Cornea / pathology*
  • Corneal Stroma / pathology*
  • Female
  • Humans
  • Infectious Mononucleosis* / diagnosis
  • Keratitis / etiology*
  • Keratitis / pathology
  • Male
  • Serologic Tests