Insights from a Case of Good's Syndrome (Immunodeficiency with Thymoma)

Biomedicines. 2023 Jun 1;11(6):1605. doi: 10.3390/biomedicines11061605.


Immunodeficiency with thymoma was described by R.A. Good in 1954 and is also named after him. The syndrome is characterized by hypogammaglobulinemia associated with thymoma and recurrent infections, bacterial but also viral, fungal and parasitic. Autoimmune diseases, mainly pure red cell aplasia, other hematological disorders and erosive lichen planus are a common finding. We describe here a typical case exhibiting all these clinical features and report a detailed immunophenotypic assessment, as well as the positivity for autoantibodies against three cytokines (IFN-alpha, IL-6 and GM-CSF), which may add to known immune abnormalities. A review of the published literature, based on case series and immunological studies, offers some hints on the still unsolved issues of this rare condition.

Keywords: Good’s syndrome; autoantibodies; cellular immunity; hypogammaglobulinemia; immunophenotype; thymoma.

Publication types

  • Case Reports

Grants and funding

This research received no external funding.