Protective effect of inosine on adrenaline-induced myocardial necrosis

Pharmacol Res Commun. 1986 May;18(5):459-69. doi: 10.1016/0031-6989(86)90166-9.

Abstract

The influence of inosine (200 and 400 mg/kg i.p.) on adrenaline-induced myocardial necrosis in rats was studied. Adrenaline in a single dose (1 and 2 mg/kg s.c.) produced heart cell necrosis estimated by plasma activities of CPK-MB, CPK, blood lactates concentration and histopathological examination. In experimental groups inosine injected simultaneously and 10 minutes after adrenaline evoked significant suppression of CPK-MB and CPK enhancement measured 4 and 24 hours after adrenaline administration. The lower blood lactates concentration 4 hours after adrenaline injection was also found when preceded by inosine. Histopathological examination showed marked protection of the affected myocardium.

MeSH terms

  • Animals
  • Creatine Kinase / blood
  • Epinephrine / antagonists & inhibitors*
  • Heart / drug effects*
  • Inosine / pharmacology*
  • Lactates / blood
  • Male
  • Myocardium / pathology
  • Necrosis
  • Rats

Substances

  • Lactates
  • Inosine
  • Creatine Kinase
  • Epinephrine