The Pathogenesis of Cytomegalovirus and Other Viruses Associated with Hearing Loss: Recent Updates

Xinyu Shi; Xiaozhou Liu; Yu Sun

doi:10.3390/v15061385

The Pathogenesis of Cytomegalovirus and Other Viruses Associated with Hearing Loss: Recent Updates

Viruses. 2023 Jun 16;15(6):1385. doi: 10.3390/v15061385.

Authors

Xinyu Shi¹, Xiaozhou Liu¹, Yu Sun^{1

2

3}

Affiliations

¹ Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
² Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430022, China.
³ Institute of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Abstract

Virus infection is one of the most common etiologies of hearing loss. Hearing loss associated with viral infection can be unilateral or bilateral, mild or severe, sudden or progressive, and permanent or recoverable. Many viruses cause hearing loss in adults and children; however, the pathogenesis of hearing loss caused by viral infection is not fully understood. This review describes cytomegalovirus, the most common virus causing hearing loss, and other reported hearing loss-related viruses. We hope to provide a detailed description of pathogenic characteristics and research progress on pathology, hearing phenotypes, possible associated mechanisms, treatment, and prevention measures. This review aims to provide diagnostic and treatment assistance to clinical workers.

Keywords: SARS-CoV-2; cytomegalovirus; hearing loss; sensorineural hearing loss; virus.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cytomegalovirus
Hearing
Hearing Loss* / etiology
Hearing Loss, Sensorineural*
Humans
Virus Diseases* / complications

Grants and funding

This work was funded by the National Nature Science Foundation of China (No: 82071508) and the National Key Research and Development Program of China (No. 2021YFF0702303).