This article proposes a historical recontextualisation of the mind-body relationship and offers some evidence-based reflections on the current clinical appropriateness of psyche-soma dichotomy and psychosomatics. The debate concerning the mind-body relationship has a long medical, philosophical, and religious history, with psyche-soma dichotomy and psychosomatics alternating as the dominant clinical approach, depending on the prevalence of cultural orientations at different times. However, both models simultaneously benefit and limit the clinical practice.The neurosciences have reduced the gap between psyche and soma diseases, which can now be seen as overlapping and sharing a common pathogenesis. Diseases should also be considered as illnesses by considering all of their biopsychosocial aspects to avoid therapeutic failures due to only partially effective or ineffective interventions. Patient-centred care integrated with guideline recommendations may be the best means of uniting the psyche and the soma.