Functions, mechanisms, and clinical applications of lncRNA LINC00857 in cancer pathogenesis

Hussein Aldayyeni; Ahmed Hjazi; Sana Shahab; Jitendra Gupta; Hashem O Alsaab; Yaseen Hasan Motea; Adeeb Abdulally Abdulhussien Alazbjee; Rosario Mireya Romero-Parra; Rasha Fadhel Obaid; Beneen M Hussien; Seyed Reza Hosseini-Fard

doi:10.1007/s13577-023-00936-0

Functions, mechanisms, and clinical applications of lncRNA LINC00857 in cancer pathogenesis

Hum Cell. 2023 Sep;36(5):1656-1671. doi: 10.1007/s13577-023-00936-0. Epub 2023 Jun 28.

Affiliations

¹ Nottingham University Hospital, NHS Trust, Nottingham, UK.
² Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.
³ Department of Business Administration, College of Business Administration, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia.
⁴ Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, 281406, India.
⁵ Department of Pharmaceutics and Pharmaceutical Technology, Taif University, Taif, 21944, Saudi Arabia.
⁶ College of Dentistry, Al-Bayan University, Baghdad, Iraq.
⁷ College of Medicine, Al-Ayen University, Thi-Qar, Nasiriyah, Iraq.
⁸ Universidad Continental, Lima, Perú. rosarioromeroparra@gmail.com.
⁹ Department of Biomedical Engineering, Al-Mustaqbal University College, Babylon, Iraq.
¹⁰ Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq.
¹¹ Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 37378889
DOI: 10.1007/s13577-023-00936-0

Abstract

Emerging data indicated that long noncoding RNAs (lncRNAs) are crucial players in the biological processes via regulating epigenetics, transcription, and protein translation. A novel lncRNA, LINC00857, was indicated to upregulate in several types of cancer. In addition, LINC00857 was functionally related to the modulation of the cancer-linked behaviors, including invasion, migration, proliferation, epithelial-mesenchymal transition (EMT), cell cycle, and apoptosis. The importance of LINC00857 in cancer onset and development proposed that LINC00857 has major importance in the cancer progression and may be considered as a novel prognostic/diagnostic biomarker as well as a treatment target. Here, we retrospectively investigate the available progress in biomedical research investigating the functions of LINC00857 in cancer, focusing on finding the molecular mechanisms affecting various cancer-related behaviors and exploring its clinical applications.

Keywords: Cancer; LINC00857; LncRNA; Oncogene.

Publication types

Review

MeSH terms

Carcinogenesis* / genetics
Cell Cycle
Cell Line, Tumor
Cell Movement / genetics
Cell Proliferation / genetics
Epigenesis, Genetic / genetics
Epithelial-Mesenchymal Transition / genetics
Gene Expression Regulation, Neoplastic / genetics
Humans
Lung Neoplasms / genetics
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism
Retrospective Studies

Substances

RNA, Long Noncoding
LINC00857 lnc, human

Grants and funding

PNURSP2023R259/Princess Nourah Bint Abdulrahman University