Update on the treatment of cancer cachexia

Drug Discov Today. 2023 Sep;28(9):103689. doi: 10.1016/j.drudis.2023.103689. Epub 2023 Jun 28.


Cancer cachexia is a complex multifaceted syndrome involving functional impairment and changes in body composition that cannot be reversed by nutritional support. Cancer cachexia is characterized by decreased skeletal muscle mass, increased lipolysis, and decreased food intake. Cancer cachexia decreases chemotherapy tolerance as well as quality of life. However, because no fully effective interventions are available, cancer cachexia remains an unmet need in cancer treatment. In recent years, several discoveries and treatments for cancer cachexia have been studied, and guidelines have been published. We believe that the development of effective strategies for the diagnosis and treatment of cancer cachexia will lead to breakthroughs in cancer treatment.

Keywords: anorexia; cachexia; cancer therapy; malnutrition; weight loss.

Publication types

  • Review

MeSH terms

  • Anorexia / etiology
  • Cachexia* / drug therapy
  • Cachexia* / etiology
  • Humans
  • Neoplasms* / complications
  • Quality of Life