Hypoferremia of inflammation: Innate host defense against infections

Tomas Ganz; Elizabeta Nemeth

doi:10.1016/j.bcmd.2023.102777

Hypoferremia of inflammation: Innate host defense against infections

Blood Cells Mol Dis. 2024 Jan:104:102777. doi: 10.1016/j.bcmd.2023.102777. Epub 2023 Jun 21.

Authors

Tomas Ganz¹, Elizabeta Nemeth²

Affiliations

¹ Department of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave., Los Angeles, CA 90095-1690, USA; Department of Pathology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave., Los Angeles, CA 90095-1690, USA. Electronic address: tganz@mednet.ucla.edu.
² Department of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave., Los Angeles, CA 90095-1690, USA.

PMID: 37391347
DOI: 10.1016/j.bcmd.2023.102777

Abstract

Iron is an essential nutrient for microbes, plants and animals. Multicellular organisms have evolved multiple strategies to control invading microbes by restricting microbial access to iron. Hypoferremia of inflammation is a rapidly-acting organismal response that prevents the formation of iron species that would be readily accessible to microbes. This review takes an evolutionary perspective to explore the mechanisms and host defense function of hypoferremia of inflammation and its clinical implications.

Keywords: Ferroportin; Hepcidin; Interleukin-6; Non-transferrin bound iron; Nutritional immunity.

Publication types

Review

MeSH terms

Animals
Hepcidins*
Inflammation*
Iron

Substances

Hepcidins
Iron