[A case of multiple small cerebral infarcts in the cerebellum and bilateral cerebrum, diagnosed with amyloid angiopathy by brain biopsy]

Rinsho Shinkeigaku. 2023 Jul 22;63(7):456-460. doi: 10.5692/clinicalneurol.cn-001845. Epub 2023 Jun 30.
[Article in Japanese]

Abstract

An 82-year-old woman had been suffering from progressive forgetfulness and abnormal speech and behavior for One month. Findings of the MRI of the head indicated scattered small cerebral infarcts in the cerebellum and in bilateral cerebral cortex/subcortical white matter. After admission, she experienced a subcortical hemorrhage, and the percentage of small cerebral infarcts increased over time. Based on the suspicion of central primary vasculitis or malignant lymphoma, we performed a brain biopsy targeting the right temporal lobe hemorrhage site, and the patient was diagnosed with cerebral amyloid angiopathy (CAA). We conclude that CAA can cause multiple small progressive cerebral infarcts.

Keywords: amyloid angiopathy; amyloid beta-related angiitis (ABRA); brain biopsy; cerebral hemorrhage; cerebral infarction.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged, 80 and over
  • Biopsy / adverse effects
  • Cerebellum / diagnostic imaging
  • Cerebellum / pathology
  • Cerebral Amyloid Angiopathy* / complications
  • Cerebral Amyloid Angiopathy* / diagnostic imaging
  • Cerebral Hemorrhage / diagnostic imaging
  • Cerebral Hemorrhage / etiology
  • Cerebral Infarction / complications
  • Cerebral Infarction / etiology
  • Cerebrum* / pathology
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • White Matter* / pathology

Supplementary concepts

  • Amyloid angiopathy