Prepregnancy body mass index and glycated albumin in the third trimester may predict infant complications in gestational diabetes mellitus: a retrospective cohort study

Daisuke Sugawara; Eishi Makita; Misa Matsuura; Hiroaki Sato; Tomoyuki Kuwata; Ko Ichihashi

doi:10.1007/s13340-023-00631-3

Prepregnancy body mass index and glycated albumin in the third trimester may predict infant complications in gestational diabetes mellitus: a retrospective cohort study

Diabetol Int. 2023 Apr 19;14(3):280-287. doi: 10.1007/s13340-023-00631-3. eCollection 2023 Jul.

Authors

Daisuke Sugawara¹, Eishi Makita¹, Misa Matsuura¹, Hiroaki Sato¹, Tomoyuki Kuwata², Ko Ichihashi¹

Affiliations

¹ Department of Pediatrics, Saitama Medical Center Jichi Medical University, 1-847 Amanuma-Cho, Saitama, 330-8503 Japan.
² Department of Obstetrics and Gynecology, Saitama Medical Center Jichi Medical University, 1-847 Amanuma-Cho, Saitama, 330-8503 Japan.

Abstract

Background: Maternal hyperglycemia, obesity, and hypertension with gestational diabetes mellitus (GDM) are risk factors for infant complications. This study aimed to investigate maternal factors and glycemic control indicators that affect infant complications in GDM.

Methods: We conducted a retrospective cohort study including 112 mothers with GDM and their infants. Multivariate logistic regression analysis was used to investigate the variables associated with good and adverse infant outcomes. We determined the cutoff values of variables that showed a significant difference in the multivariate logistic regression analysis for predicting infant complications by performing receiver operating characteristic curve analysis.

Results: In the multivariate logistic regression analysis, prepregnancy BMI and GA in the third trimester were significantly related to good and adverse infant outcomes (adjusted odds ratios [aORs], 1.62; 95% CIs 1.17-2.25, p = 0.003 and aORs, 2.77; 95% CIs 1.15-6.64, p = 0.022, respectively). The cutoff values for prepregnancy BMI and GA in the third trimester were 25.3 kg/m2 and 13.5%, respectively.

Conclusions: The importance of weight control before pregnancy and the usefulness of GA in the third trimester to predict infant complications were suggested in this study.

Keywords: Body mass index; Gestational diabetes mellitus; Glycated albumin; Glycated hemoglobin; Infant complication.

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