Contact sensitivity to the amide anesthetics lidocaine, prilocaine, and mepivacaine. Case report and review of the literature

Arch Dermatol. 1986 Aug;122(8):924-6.


Multiple sensitivities to amide local anesthetics occurred in a 70-year-old woman following dental treatment. Soft-tissue swelling of the cheek was the clinical presentation. Patch testing confirmed type IV hypersensitivity to lidocaine, prilocaine, mepivacaine, and dibucaine. We review the classification of local anesthetics and the literature relating to contact sensitivity to the amide group.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Amides
  • Anesthesia, Dental
  • Anesthetics, Local / adverse effects*
  • Cross Reactions
  • Dermatitis, Contact / etiology*
  • Female
  • Humans
  • Lidocaine / adverse effects
  • Mepivacaine / adverse effects
  • Patch Tests
  • Prilocaine / adverse effects


  • Amides
  • Anesthetics, Local
  • Prilocaine
  • Lidocaine
  • Mepivacaine