Effect of Two Years of Doxycycline Treatment on Infrarenal Aortic Neck Diameter

Annalise M Panthofer; Sydney L Olson; Brooks L Rademacher; Larry W Kraiss; William C Blackwelder; B Timothy Baxter; Jason N MacTaggart; Barry T Katzen; Scott S Berman; Jon S Matsumura; N-TA3CT investigators

doi:10.1016/j.ejvsvf.2023.05.011

Effect of Two Years of Doxycycline Treatment on Infrarenal Aortic Neck Diameter

EJVES Vasc Forum. 2023 May 24:59:43-48. doi: 10.1016/j.ejvsvf.2023.05.011. eCollection 2023.

Affiliations

¹ Department of Surgery, Division of Vascular Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
² Department of Surgery, Division of Vascular Surgery, University of Utah, Salt Lake City, UT, USA.
³ Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
⁴ Department of Surgery, Division of Vascular Surgery, University of Nebraska Medical Centre, Omaha, NE, USA.
⁵ Miami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, FL, USA.
⁶ Pima Heart and Vascular, Tucson, AZ, USA.

Abstract

Objective: Endovascular aneurysm repair (EVAR) is a widely used option for patients with suitable vascular anatomy who have a large infrarenal abdominal aortic aneurysm (AAA). Neck diameter is the primary anatomical determinant of EVAR eligibility and device durability. Doxycycline has been proposed to stabilise the proximal neck after EVAR. This study explored doxycycline mediated aortic neck stabilisation in patients with small AAA, monitored by computed tomography over two years.

Methods: This was a multicentre prospective randomised clinical trial. Subjects from the Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA³CT, NCT01756833) were included in this secondary a priori analysis. Female baseline AAA maximum transverse diameter was between 3.5 and 4.5 cm, and male was between 3.5 and 5.0 cm. Subjects were included if they completed pre-enrolment and two year follow up computed tomography (CT) imaging. Proximal aortic neck diameter was measured at the lowest renal artery, and 5, 10, and 15 mm caudal to this point; mean neck diameter was calculated from these values. Unpaired, two tailed parametric t test analysis with post hoc Bonferroni correction was used to detect differences between neck diameters in subjects treated with placebo vs. doxycycline at baseline and two years.

Results: One hundred and ninety-seven subjects (171 male, 26 female) were included in the analysis. All patients, regardless of treatment arm, demonstrated larger neck diameter caudally, a slight increase in diameter at all anatomical levels over time, and greater growth caudally. There was no statistically significant difference in infrarenal neck diameter between treatment arms at any anatomical level at any time point, nor mean change in neck diameter over two years.

Conclusion: Doxycycline does not demonstrate infrarenal aortic neck growth stabilisation in small AAA followed for two years by thin cut CT imaging using a standardised acquisition protocol and cannot be recommended for mitigation of growth of the aortic neck in patients with untreated small abdominal aortic aneurysms.

Keywords: Abdominal aortic aneurysm; Endovascular procedures; Spiral computed tomography.