An miRNA with a major impact on stress

Sarah Cooper Simmons; A J Robison

doi:10.1016/j.tig.2023.06.005

An miRNA with a major impact on stress

Trends Genet. 2023 Sep;39(9):642-643. doi: 10.1016/j.tig.2023.06.005. Epub 2023 Jul 4.

Authors

Sarah Cooper Simmons¹, A J Robison²

Affiliations

¹ Department of Physiology, Michigan State University, East Lansing, MI 48824, USA.
² Department of Physiology, Michigan State University, East Lansing, MI 48824, USA. Electronic address: robiso45@msu.edu.

PMID: 37414676
PMCID: PMC10526973 (available on 2024-09-01)
DOI: 10.1016/j.tig.2023.06.005

Abstract

miRNAs regulate mRNAs, including those important for synapse function in the brain. Mucha and colleagues recently identified a novel miRNA-mRNA interaction in the basolateral amygdala that acts as a homeostatic counter to stress-induced anxiety and synaptic changes, suggesting miRNAs as potential avenues for therapeutic intervention in anxiety disorders.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Brain
MicroRNAs* / genetics

Substances

MicroRNAs

Grants and funding

R01 MH111604/MH/NIMH NIH HHS/United States