Senolytics combat COVID-19 in aging

Nat Aging. 2023 Jul;3(7):762-763. doi: 10.1038/s43587-023-00450-w.

Abstract

Aging increases vulnerability to respiratory viral-infections, including SARS-CoV-2. Delval et al. established a causal role for age-related pre-existing senescent cells, in the severity of COVID-19 symptoms in an ageing hamster model. Selective depletion of senescent cells, using senolytics, was shown to mitigate the risk of severe COVID-19 symptoms linked to aging.

Publication types

  • News
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Aged
  • COVID-19 Drug Treatment* / methods
  • COVID-19*
  • Cellular Senescence / drug effects
  • Humans
  • Senotherapeutics* / pharmacology

Substances

  • Senotherapeutics