Acute effects of ethanol on protein synthesis in the rat

Alcohol Alcohol. 1986;21(2):171-9.

Abstract

The effect of ethanol, administered acutely (75 mmol kg-1), on protein synthesis in the whole body and in the tissues of the rat was investigated. Ethanol decreased whole-body protein synthesis by 41% and also that in individual tissues (liver: 60%; muscle: 75%; heart: 45%; kidney: 59%; spleen: 73%; plasma protein: 44%; lung: 64%). These data indicate a generalised effect upon protein synthesis and are discussed in relation to the possible mode of action of ethanol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Ethanol / blood
  • Ethanol / pharmacology*
  • Female
  • Kidney / drug effects
  • Kinetics
  • Liver / drug effects
  • Protein Biosynthesis*
  • Rats
  • Rats, Inbred Strains
  • Tyrosine / metabolism

Substances

  • Ethanol
  • Tyrosine