MicroRNA electrochemical biosensors for pancreatic cancer

Clin Chim Acta. 2023 Aug 1:548:117472. doi: 10.1016/j.cca.2023.117472. Epub 2023 Jul 5.


Pancreatic cancer (PC) is one of the deadliest cancers worldwide. MicroRNAs (miRs) are sensitive molecular diagnostic tools that can serve as highly accurate biomarkers in many disease states in general and cancer specifically. MiR-based electrochemical biosensors can be easily and inexpensively manufactured, making them suitable for clinical use and mass production for point-of-care use. This paper reviews nanomaterial-enhanced miR-based electrochemical biosensors in pancreatic cancer detection, analyzing both labeled and label-free approaches, as well as enzyme-based and enzyme-free methods.

Keywords: Biosensor; Diagnosis; MicroRNA; Pancreatic cancer.

Publication types

  • Review

MeSH terms

  • Biosensing Techniques* / methods
  • Electrochemical Techniques / methods
  • Humans
  • MicroRNAs* / genetics
  • Nanostructures*
  • Pancreatic Neoplasms* / diagnosis
  • Pancreatic Neoplasms* / genetics


  • MicroRNAs

Supplementary concepts

  • Pancreatic Carcinoma