Lower Urinary Tract Obstruction in Newborns

Adv Pediatr. 2023 Aug;70(1):131-144. doi: 10.1016/j.yapd.2023.03.001. Epub 2023 May 15.


Lower urinary tract obstruction (LUTO) is a rare birth defect with a prevalence between 1 in 5,000 and 1 in 25,000 pregnancies. LUTO is one of the most common causes of congenital abnormalities of the renal tract. Several genetic conditions have been associated with LUTO. Most common causes of LUTO are posterior urethral valves and urethral atresia. Despite available prenatal and postnatal treatments, LUTO is a significant cause of morbidity and mortality in newborns causing significant end stage renal disease and pulmonary hypoplasia.

Keywords: End-stage renal disease; Lower urinary tract obstruction; Posterior urethral valves; Prune belly syndrome; Pulmonary hypoplasia; Urethral atresia.

Publication types

  • Review

MeSH terms

  • Female
  • Humans
  • Infant, Newborn
  • Kidney
  • Pregnancy
  • Retrospective Studies
  • Ultrasonography, Prenatal
  • Urethral Obstruction* / diagnosis
  • Urethral Obstruction* / epidemiology
  • Urethral Obstruction* / etiology
  • Urinary Tract* / abnormalities