Effect of budesonide combined with montelukast sodium on pulmonary function parameters and immunoglobulin levels in children with bronchial asthma

Allergol Immunopathol (Madr). 2023 Jul 1;51(4):151-157. doi: 10.15586/aei.v51i4.897. eCollection 2023.

Abstract

Background and aim: Bronchial asthma is a prevalent type of respiratory disease that affects a large proportion of pediatric patients. The purpose of this study is to further investigate the clinical effects of budesonide combined with montelukast sodium in treating bronchial asthma.

Methods: Eighty six children with bronchial asthma were equally divided into study and control groups via randomized double-blind controlled trial. The control group was treated with aerosol inhalation of budesonide combined with placebo, while the study group was treated with budesonide combined with montelukast sodium. Pulmonary function parameters, immunoglobulin, and recovery of related symptoms, along with the adverse reaction rate, were observed and compared between both groups.

Results: Before treatment, there was no marked difference in pulmonary function parameters and immunoglobulin indexes between both groups (P > 0.05). All pulmonary function indicators and immunoglobulin indexes in both groups improved following therapy, with the study group outperforming the control group (P < 0.05). The recovery time of related symptoms in the study group was shorter than that in the control group (P < 0.05). The incidence of adverse reactions in both groups was compared, with notable differences (P < 0.05).

Conclusion: Budesonide combined with montelukast sodium in the treatment of bronchial asthma has the value of clinical application and promotion.

Keywords: bronchial asthma; budesonide; immunoglobulin; montelukast sodium; pulmonary function.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acetates / therapeutic use
  • Administration, Inhalation
  • Anti-Asthmatic Agents* / therapeutic use
  • Asthma* / chemically induced
  • Asthma* / drug therapy
  • Budesonide / therapeutic use
  • Child
  • Humans
  • Quinolines* / therapeutic use

Substances

  • Budesonide
  • montelukast
  • Anti-Asthmatic Agents
  • Acetates
  • Quinolines