Nanomedicine innovations in spinal cord injury management: Bridging the gap

Mohsen Rahmanian; Amirali Ghahremani; Prashant Kesharwani; Fatemeh Oroojalian; Amirhossein Sahebkar

doi:10.1016/j.envres.2023.116563

Nanomedicine innovations in spinal cord injury management: Bridging the gap

Environ Res. 2023 Oct 15:235:116563. doi: 10.1016/j.envres.2023.116563. Epub 2023 Jul 7.

Authors

Mohsen Rahmanian¹, Amirali Ghahremani², Prashant Kesharwani³, Fatemeh Oroojalian⁴, Amirhossein Sahebkar⁵

Affiliations

¹ School of Medicine, North Khorasan University of Medical Sciences, Bojnord, Iran.
² Department of Neurology, North Khorasan University of Medical Sciences, Bojnord, Iran.
³ Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India; Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India. Electronic address: prashantdops@gmail.com.
⁴ Department of Advanced Technologies, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran; Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran. Electronic address: f.oroojalian@ut.ac.ir.
⁵ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: sahebkara@mums.ac.ir.

PMID: 37423366
DOI: 10.1016/j.envres.2023.116563

Abstract

Spinal cord injury (SCI) has devastating effects on a person's physical, social, and professional well-being. It is a life-altering neurological condition that significantly impacts individuals and their caregivers on a socioeconomic level. Recent advancements in medical therapy have greatly improved the diagnosis, stability, survival rates, and overall well-being of SCI patients. However, there are still limited options available for enhancing neurological outcomes in these patients. The complex pathophysiology of SCI, along with the numerous biochemical and physiological changes that occur in the damaged spinal cord, contribute to this gradual improvement. Currently, there are no therapies that offer the possibility of recovery for SCI, although several therapeutic approaches are being developed. However, these therapies are still in the early stages and have not yet demonstrated effectiveness in repairing the damaged fibers, which hinders cellular regeneration and the full restoration of motor and sensory functions. Considering the importance of nanotechnology and tissue engineering in treating neural tissue injuries, this review focuses on the latest advancements in nanotechnology for SCI therapy and tissue healing. It examines research articles from the PubMed database that specifically address SCI in the field of tissue engineering, with an emphasis on nanotechnology as a therapeutic approach. The review evaluates the biomaterials used for treating this condition and the techniques employed to create nanostructured biomaterials.

Keywords: Biomaterials; Central nervous system; Eeurological disease; Nanotechnology; Spinal cord injury; Tissue engineering.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials / therapeutic use
Humans
Nanomedicine*
Nanotechnology
Spinal Cord Injuries* / drug therapy

Substances

Biocompatible Materials