3D bioprinting for organ and organoid models and disease modeling

Expert Opin Drug Discov. 2023 Jul-Dec;18(9):1043-1059. doi: 10.1080/17460441.2023.2234280. Epub 2023 Jul 11.


Introduction: 3D printing, a versatile additive manufacturing technique, has diverse applications ranging from transportation, rapid prototyping, clean energy, and medical devices.

Areas covered: The authors focus on how 3D printing technology can enhance the drug discovery process through automating tissue production that enables high-throughput screening of potential drug candidates. They also discuss how the 3D bioprinting process works and what considerations to address when using this technology to generate cell laden constructs for drug screening as well as the outputs from such assays necessary for determining the efficacy of potential drug candidates. They focus on how bioprinting how has been used to generate cardiac, neural, and testis tissue models, focusing on bio-printed 3D organoids.

Expert opinion: The next generation of 3D bioprinted organ model holds great promises for the field of medicine. In terms of drug discovery, the incorporation of smart cell culture systems and biosensors into 3D bioprinted models could provide highly detailed and functional organ models for drug screening. By addressing current challenges of vascularization, electrophysiological control, and scalability, researchers can obtain more reliable and accurate data for drug development, reducing the risk of drug failures during clinical trials.

Keywords: Organoids; bioinks; bioprinting; cardiac; neural; stem cells.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bioprinting*
  • Drug Evaluation, Preclinical
  • Humans
  • Organoids
  • Printing, Three-Dimensional
  • Tissue Engineering* / methods

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