Immune Profiling of Meningiomas

Adv Exp Med Biol. 2023:1416:189-198. doi: 10.1007/978-3-031-29750-2_14.


Though meningiomas are generally regarded as benign tumors, there is increasing awareness of a large group of meningiomas that are biologically aggressive and refractory to the current standards of care treatment modalities. Coinciding with this has been increasing recognition of the important that the immune system plays in mediating tumor growth and response to therapy. To address this point, immunotherapy has been leveraged for several other cancers such as lung, melanoma, and recently glioblastoma in the context of clinical trials. However, first deciphering the immune composition of meningiomas is essential in order to determine the feasibility of similar therapies for these tumors. Here in this chapter, we review recent updates on characterizing the immune microenvironment of meningiomas and identify potential immunological targets that hold promise for future immunotherapy trials.

Keywords: B cells; Immune microenvironment; Immunosuppression; Immunotherapy; Macrophages; PD-L1; T cells.

Publication types

  • Review

MeSH terms

  • Glioblastoma*
  • Humans
  • Immunotherapy
  • Melanoma*
  • Meningeal Neoplasms* / therapy
  • Meningioma* / therapy
  • Tumor Microenvironment