Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1Alpha (PGC-1α): A Transcriptional Regulator at the Interface of Aging and Age-Related Macular Degeneration?

Freya M Mowat

doi:10.1007/978-3-031-27681-1_8

Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1Alpha (PGC-1α): A Transcriptional Regulator at the Interface of Aging and Age-Related Macular Degeneration?

Adv Exp Med Biol. 2023:1415:49-53. doi: 10.1007/978-3-031-27681-1_8.

Author

Freya M Mowat¹

Affiliation

¹ Department of Ophthalmology and Visual Sciences (School of Medicine and Public Health), Department of Surgical Sciences (School of Veterinary Medicine), Medical Sciences Center, University of Wisconsin-Madison, Madison, WI, USA. mowat@wisc.edu.

PMID: 37440013
DOI: 10.1007/978-3-031-27681-1_8

Abstract

Human age-related macular degeneration (AMD) is a prevalent age-related disease which causes retinal dysfunction and disability. Genetic and cell culture studies from AMD patients have implicated impaired activity of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1α). PGC-1α is a transcriptional co-regulator that acts to control a plethora of metabolic processes relevant to AMD pathophysiology including gluconeogenesis, oxidative phosphorylation, and response to oxidative injury. Perturbation of PGC-1α activity in mice causes AMD-like RPE and retinal pathology. There is potential for therapeutic modulation of the PGC-1α pathway in AMD treatment.

Keywords: Age-related macular degeneration; Aging; Metabolism; PGC-1alpha; PPARGC-1alpha; Retina.

MeSH terms

Aging / genetics
Animals
Humans
Macular Degeneration* / pathology
Mice
Mitochondria / metabolism
Oxidative Stress
PPAR gamma*
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / genetics

Substances

PPAR gamma
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha