Effect of COVID-19 inactivated vaccine on peripheral blood anti-β2-GPI antibody and outcomes in vitro fertilization-embryo transplantation

Huiling Zhou; Yilu Zou; Yujia Guo; Xiaoting Lv; Jiajing Chen; Xinxin Guo; Qicai Liu

doi:10.1016/j.intimp.2023.110596

Effect of COVID-19 inactivated vaccine on peripheral blood anti-β₂-GPI antibody and outcomes in vitro fertilization-embryo transplantation

Int Immunopharmacol. 2023 Sep:122:110596. doi: 10.1016/j.intimp.2023.110596. Epub 2023 Jul 11.

Authors

Huiling Zhou¹, Yilu Zou², Yujia Guo¹, Xiaoting Lv³, Jiajing Chen¹, Xinxin Guo⁴, Qicai Liu⁵

Affiliations

¹ Department of Reproductive Medicine Center, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China.
² Department of Reproductive Medicine Center, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China; Fujian Provincial Key Laboratory of Stem Cell Engineering and Regenerative Medicine, Fuzhou 350004, Fujian, China.
³ Department of Respiratory and Critical Care Medicine, Research Laboratory of the Respiratory System Diseases, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China.
⁴ Department of Reproductive Medicine Center, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China; Fujian Provincial Key Laboratory of Stem Cell Engineering and Regenerative Medicine, Fuzhou 350004, Fujian, China. Electronic address: guoxin90@fjmu.edu.cn.
⁵ Department of Reproductive Medicine Center, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China. Electronic address: liuqc2000@yeah.net.

PMID: 37441812
DOI: 10.1016/j.intimp.2023.110596

Abstract

Corona Virus Disease 2019 (COVID-19) is an acute respiratory infection and a global public health event. The level of aβ₂GPI is significantly up-regulated in COVID-19 patients. The impact of inactivated vaccination against COVID-19 on aβ₂GPI and in vitro fertilization and embryo transfer (IVF-ET) remains unknown amidst the universal administration of COVID-19 vaccines. We conducted a retrospective study to assess the impact of COVID-19 inactivated vaccination on aβ₂GPI levels and its effect on superovulation and pregnancy outcomes. We found aβ₂GPI level is significantly up-regulated after vaccination. There was no statistical difference in mature egg rate, 2PN fertilization rate, day 3 high-quality embryo rate, blastocyst formation rate, embryo implantation rate and miscarriage rate between the vaccine group and control group. Our findings showed vaccination with COVID-19 inactivated vaccine can elevate the level of aβ₂GPI in peripheral blood but have no effect on the outcomes of controlled ovarian hyperstimulation and pregnancy in IVF-ET.

Keywords: Anti-β(2) glycoprotein I antibody; COVID-19; COVID-19 inactivated vaccine; Controlled ovarian hyperstimulation; In vitro fertilization-embryo transfer.

MeSH terms

COVID-19 Vaccines*
COVID-19* / prevention & control
Embryo Transfer
Female
Fertilization in Vitro
Humans
Pregnancy
Retrospective Studies
Vaccines, Inactivated
beta 2-Glycoprotein I

Substances

COVID-19 Vaccines
beta 2-Glycoprotein I
Vaccines, Inactivated